SUCCESS: Series of Unique Creative Continuing Education Self Studies

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IgG Structure and Function Effect on Hemolytic Disease of the Newborn and Neonatal Alloimmune Thrombocytopenia Severity (Release Date: 05/07/2018) Hemolytic Disease of the Newborn (HDN) and Neonatal Alloimmune Thrombocytopenia (NAIT) pose significant morbidity and mortality risk.  Prevention and early detection are key.  Recent studies have described a correlation between immunoglobulin structure and clinical severity.  Typical IgG structure and immunoglobulin structural alterations along with the study results will be presented.

Indications for Transfusion (Release Date: 06/14/2017) Indications are established reasons for transfusion, which will benefit the patient. However blood components are drugs and can have adverse effects and should not be administered indiscriminately. This course will highlight the main indications and some of the adverse effects that can occur with the transfusion of red blood cells, plasma, and platelets.

Clinical Case conference: Autoimmune hemolytic anemia (Release Date: 04/10/2015) Anemia can result from different causes and and correctly diagnosing its source can be challenging. Transfusion therapies that will result in successful clinical management of anemia require correct laboratory diagnosis. Prompt recognition of suspected reactions and cessation of transfusion limit their severity and can prevent fatalities. This course provides an overview of adverse transfusion reactions and reviews steps to prevent them or limit their severity.

What's New with Granulocyte Transfusions (Release Date: 07/01/2009)
Issues related to granulocyte transfusions are reviewed, including indications for transfusion, ordering products and administration. Product-related issues including regulations, product dose and donor safety are covered. Future research efforts are highlighted. NOTE: when you review the lecture on granulocytes, you will see references to the RING Study.  This study was designed to test the efficacy of high doses of granulocytes and antimicrobial therapy compared to antimicrobial therapy alone in neutropenic patients.  The study failed to accrue the targeted number of patients and closed in 2014.  There was no difference between the two groups, but because of the low accrual, the study was under-powered. 

Septic Transfusion Reactions: Lessons from the Headlines and Hemovigilance (Release date: 12/07/2015) Septic reactions from apheresis platelet transfusion are a leading cause of morbidity and mortality, but there are opportunities to increase awareness, recognition and reporting that could improve safety for patients. 

Practical Coagulation for the Blood Bank (Release date: 06/30/2016) This course provides a summary of the general coagulation model which includes initiation, amplification and propagation. There is also a look at thrombin’s role in clot formation as well as a review of the common coagulation tests and the major drugs used in coagulation abnormalities.

An Introduction to Pathogen Reduction (Release date: 08/31/2016) This course defines the concept of pathogen reduction, describes the pathogen reduction systems available for blood components and summarizes the studies conducted to date.

FDA Draft Guidance on Platelet Safety (release date: 09/19/2017) This course review the significant elements of the FDA Draft Guidance on mitigation of bacterial contamination in platelets. This learning material also identifies the challenges for implementation of the proposed process changes and addresses how the Final Guidance may appear after public comments have been submitted and reviewed.