CEU COURSE- ALL THINGS RH

This lecture presents an overview of the genetics of the RH blood group system and how it impacts the transfusion service. The genetic variation in the RH system is discussed in the context of typing discrepancies, the serologic weak D phenotype and candidacy for Rh immune globulin in pregnancy. The learner will become familiar with the 2015 recommendation to “phase in” RHD genotyping as well as the recent 2020 recommendation to “phase out” resulting a patient as “weak D+” without RHD genotyping to determine risk of alloimmunization. RHCE variants are discussed as well as the use of RH allele matching for patients who have made antibodies to high prevalence antigens such as hrB.

TARGET AUDIENCE/PREREQUISITES: Technologists, technicians and laboratory managers 

LEVEL: Intermediate

SUCCESSTM CREDITS: 1.0 CEU

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LEARNING OBJECTIVES
At the conclusion of this activity, participants should be able to:

  1. Describe the RH locus, the RhD and Rhce proteins and the common Rh antigens.
  2. Illustrate the limitations of serologic testing and strengths of molecular testing to predict antigens.
  3. Discuss the AABB recommendations regarding use of RHD genotyping to resolve a serologic weak D phenotype
  4. Use cases to illustrate how RHD genotyping can aid in determination of risk of alloimmunization
  5. Demonstrate how RH allele matching can be used to find compatible blood for a patient with an antibody to a high prevalence Rh antigen

LEARNING TASKS
To receive CEU credit for this activity, participants must:

  1.  Review the presentation "All Things RH" or review the slides and accompanying notes available as a printable Adobe Reader® file.
  2. Take the online Post-Test.
  3. Complete the online Activity Evaluation.
  4. Print the certificate awarding 1.0 CEU credit(R) through the SUCCESSTM program.

FACULTY
Margaret Keller, PhD
Senior Director, National Molecular Laboratory
American Red Cross Blood Services
Philadelphia, PA

DISCLAIMER
The opinions expressed in this educational activity are those of the faculty and do not necessarily represent the views of the American Red Cross Biomedical Services. 

RELEASE DATE: 05/20/2020

EXPIRATION DATE: 05/19/2023

ESTIMATED TIME TO COMPLETE ACTIVITY: 1.0 hour 

Last modified: Thursday, May 14, 2020, 05:16 PM