SUCCESS: Series of Unique Creative Continuing Education Self Studies

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Blood groups imageHh, Lewis, P1PK, Globoside, and I This presentation describes the carbohydrate-based blood group systems, Hh, Lewis, P1PK, Globoside and I.  Many antibodies to antigens in these systems are naturally-occurring, primarily cold-reactive antibodies that are generally not clinically relevant.  Some, however, can cause severe intravascular hemolysis.  Detection / identification methods and the clinical significance of these antibodies will be highlighted after a discussion of the antigens in each system.

Rh Blood Group System Beginning with a historical perspective on the Rh system, we will describe the inheritance and biochemistry of the Rh antigens. Quantitative and qualitative differences in D antigen expression, including syndromes with absent RHD and RHCE gene product expression will be reviewed. A discussion of the basis of several clinically significant high- and low-incidence antigens will round out the presentation.

The MNS Blood Group System The MNS blood group system is second in complexity to the Rh system with its many antigens and inheritance via highly homologous genes. This presentation reviews the history, inheritance, biochemistry, and serologic findings of the second blood group discovered.

The ABO Blood Group System The ABO blood group system has evolved from a three-allele system to a multiple-allele system. This presentation reviews the various alleles responsible for ABO phenotypes, the transferases and the biochemical structures they produce, and diseases associated with certain ABO blood types.

Kidd and Duffy Blood Group Systems The ABO blood group system has evolved from a three-allele system to a mulitple-allele system. The presentation reviews the various alleles responsible for ABO phenotypes, the transferases and the biochemical structures they produce, and diseases associated with various ABO types.